Methoxyflavone – MX-7 from Gen

Methoxyflavone (5-Methyl 7-methoxyisoflavone) is a non-hormonal anabolic / anti-catabolic isoflavone. This powerful flavone has been shown to increase protein synthesis, decrease cortisol levels and improve recovery from exercise.

+ Increased protein synthesis
+ Anticatabolic
+ Antiestrogenic
+ Non-hormonal anabolic
+ Increased lean tissue
+ Improved recovery

Review
Is this powerful anabolic flavone the real deal?
By Brain Batcheldor

Steroid replacement, steroid substitute, legal steroid, -how often do you open a bodybuilding magazine and read these claims? Those of us who choose to reside on planet earth know full well that no such thing exists, not if we’re talking about something that does exactly the same job. The problem is that this marketing approach has created both skepticism and, perhaps worse still, steroid awareness amongst beginners. In truth, the industry would prosper better by telling it as it is, i.e.: Nothing (zilch, nada) can do what steroids do as effectively.

An ideal approach to steroid replacement would involve a holistic system of

Nutritional programming, cyclic training and restoration techniques. An acceptance of the truth and realistic goal setting allow an athlete to get the maximum from this strategy, whether they are clean or just simply taking a break from steroids.
Creating an anabolic state within the body isn’t simply limited to anabolic hormones.
When you consider the leaps in technology that have occurred within sports nutrition in the last 3-4 years, point number three becomes a viable one to tackle. It is a factual statement, read it again carefully and think about it. What do we actually mean by an anabolic state? An anabolic state would be as follows:

A state where the delicate balance between the bodies’ anabolic processes and its catabolic ones continuously swings in favor of the anabolic side.
A state where the body deals very efficiently with protein, with good net utilization.
A state of continuous positive nitrogen balances i.e. where nitrogen taken in exceeds the amount excreted, so that some is obviously being retained. Although an expansion of the previous state, it is not exactly the same thing.
A state where the bodies’ adaptive responses effectively deal with your training regimen and, if the other factors are in place, continues to overcompensate.
When we scrutinize the above requirements, one common denominator leaps out at you almost every time, -PROTEIN! Increased protein synthesis is only one of the mechanisms by which anabolic steroids work, but this can be achieved by non-hormonal methods. In fact, even athletes that take steroids should strive to achieve this non-hormonally.

Ready for some more honest good news? One of the other mechanisms by which steroids work is keeping the catabolic side in check. You know, dealing with the old Dark Angel, cortisol, who lingers on the sidelines, waiting for you to do that one set too many, to fall short by just those few grams of protein or to skip that hour of sleep. Well guess what, -the blunting of cortisols’ effects can also be achieved through non-hormonal means.

By now, some of you may be wondering if the non-hormonal route should also mean without prohormones. In my opinion, some of the prohormones carry pretty anabolic activity even without converting to their more recognizable counterparts. Others carry the same pitfalls, maybe to an even greater degree e.g. conversion to estrogen. Coming up with improved methods of delivery like cyclodextrins, for example, simply magnifies this situation. This being the case, do we honestly believe that prohormones are anything other than a poor legal way round the steroid situation? I am 100% pro steroid but for whatever reasons many of you decide not to take them, you can probably apply them to prohormones as well, -especially when you consider that many users are taking huge dosages of them.

To be honest, we don’t fully understand the processes involved in gaining muscle, there have been whole conferences held by the scientific community on just this subject. What we do understand perhaps a little better are the mechanisms involved in muscle loss or wasting, AIDS and cancer research having provided us with much information here. If we dig deep enough, we will see that once again the eastern bloc has provided some interesting alternatives with which to approach this conundrum.

A few years ago, I was interested in finding a company who could commercially manufacture Chrysin for me at a viable price. A Company in Lithuania, Endokrinin, who manufacture the absolute finest cadaver-sourced GH you could ever wish to sell to your enemies, put me onto Chinoin in Hungary. This immediately made sense to me, as I had previously dealt with Chinoin and knew that flavones and isoflavones was definitely their area of expertise. I used to buy loads of Osteochin from them and sell it to athletes. This was a popular osteoporosis treatment that many swore by for its anabolic effects, its active ingredient being ipriflavone (7-isopropoxyisoflavone). I traveled to Budapest to discuss the Chrysin project and over the next few months they intimated to me about the development of ipriflavone. They told me how they had experimented with various isoflavones for use as anabolic agents with patients suffering from wasting conditions and livestock. One of the deciding criteria they implemented was that the isoflavones had to be devoid of estrogenic effects. This immediately excluded the following from their list:

Genistein (sorry soy fans).
Daidzin (ditto).
Biochanin.
Formomonetin.
Pratensin.
Prunetin.
Although Ipriflavone proved to be anabolic and anti-estrogenic, it was also excluded from this list, its forte being prevention of calcium loss. Therefore, Chinoin saw this as a specialist product to be marketed for use with osteoporosis. After extensive research, they came up with a short list of just four synthetic isoflavones. All proved effective at what they were looking for, but one in particular stood out, 5-methyl-7-methoxy-isoflavone or Methoxyflavone for short.

Clinical trials were run and patents were applied for in the U.S. and in Europe (late seventies) for its use as “an anabolically effective compound for use as a pharmaceutical or a feed additive”. The necessary research results were convincing enough and the patents were granted.

So what did the trials reveal about methoxy-7 that warranted the granting of a patent? In the standard rat levator ani test, used with anabolic steroids to determine their anabolic: androgenic ratio, it was determined that methoxyflavone was indeed highly anabolic, yet totally free of any androgenic effects.

With livestock, after 30 days on the compounds, the following body weight increases were recorded:

8-15% in calves
7-10% in cattle.
7-10% in hogs.
8-20% in poultry.
10-20% in rabbits.
8-12% in guinea pigs.
All gains were mainly lean tissue and were accompanied by an increase in vitality. After detailed investigation, no alteration of endocrine function was found, clearly indicating that gains were non-hormonal in origin.

In humans, these compounds demonstrated increased and faster protein utilization, via labeled albumin. With severely wasted patients suffering from pathological thinness, after a few weeks of use, a gain of 2-3 kg was noted. Not only did methoxyflavone halt the muscle wasting it increased lean tissue growth.

Another characteristic feature of the anabolic effect was increases in calcium phosphorous, potassium and nitrogen retention to a significant degree. In other experiments, the catabolic effects of cortisone were partially suppressed and it was concluded, “identical doses of anabolic steroids do not exert anabolic effects stronger than those of these compounds!”

Chinoin pointed out in their trials the important advantage of methoxyflavone over anabolic agents belonging to the sterane group (steroids) in that it does not exhibit androgenic or liver damaging effects. It also decreases oxygen consumption of tissues and lowers cholesterol.

Ironically, the only thing that Chinoin could not determine is how these compounds work. They describe the weight gains as “a very interesting novel biological effect”. They then proceed to state “these compounds show weight-yield increasing effects exceeding all effects of this type known and are at the same time practically in other respects innocuous to the living organism”. Significantly, it was also pointed out that the effects were entirely independent of the composition of the feeds used in the trials.

Unfortunately, Chinoin never did anything with these compounds. I tried to interest them in commercial manufacture of methoxyisoflavone but it was like banging my head against a wall. Their poor business attitude (i.e. “I get the same wage whether I do this or not”) and mountains of red tape pushed me in another direction. After nearly a year, I finally got a company in Estonia to produce methoxyflavone.

The preliminary results have been as impressive as the Hungarians indicated, with all of my athletes making quality lean gains. Every lifter I had in this year World Power lifting Championships struggled harder than ever to squeeze into his weight class. Recuperation also seemed to improve, with subsequent gains in strength. Dosages averaged 600 mg per day but admittedly I would have liked to try more, the price being the limiting factor here.

Although it is early days yet, this compound looks very exciting. A highly anabolic agent that is non-hormonal and therefore does not interfere with normal endocrine function, -ideal for both clean athletes and the chemically assisted, as there is no feedback inhibition of endogenous hormones. With the debate over prohormones still raging and their future looking unsure, I predict that the future of ergogenic nutrition will be in isoflavones and plant steroids.
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Thermonol – XS by Gen

THERMONOL XS is a revolutionary formula designed from the latest technology in fat loss research. This Advanced Metabolic Formula contains synergistic herbal blends that stimulate thermogenic fat loss. Thermonol XS contains the herbal extracts of Forskolin and Guggulsterones. Clinical studies have shown that these powerful compounds increase fat loss and promote lean muscle tissue as well as support thyroid function.

AJ DiCaprio Fitness Celebrity says – “THERMONOL XS’s affect is like a sneak attack! An hour after taking THERMONOL XS I began to feel a slight rise in body temperature and a time-released increase in energy. It was as if someone was slowly turning up the thermostat in the room until I began to sweat. My energy level also slowly increased. I was able to function normally before and after my workouts without fear of the jitters.

I had been used to other products that knocked me into a tailspin like a cartoon character bouncing off walls. From one extreme to another, those same products dropped me from high energy to exhaustion, leaving me fatigued yet unable to sleep. They also dehydrated me and in some cases left me with dry mouth.

THERMONOL XS gave me a slow comfortable burn, and a quality buzz that gave my workouts and my metabolism a much needed “kick in the ass” without being edgy. It’s the best metabolic fat burner I’ve come across.”

Q. I have tried just about every fat-burning product on the market. I have not been overly impressed with any of them. Tell me, why should I try THERMONOL XS.

A. Most companies that offer fat-loss products include only a few compounds that may aid in fat burning. Most of these products may help you rid yourself of a pound or two, but that’s it.

There are some companies out there that unscrupulously claim to have a vast range of fat burning compounds in their formulas. They claim their ingredients allow you to burn more body fat than ever before. But guess what they fail to tell you. They may have some fantastic ingredients for fat burning but those ingredients are not provided in amounts high enough to yield any significant results. A complete waste of time and money.

There is a company right now that has a decent formula for fat burning as far as the variety of ingredients in the formula. The problem with the formula is a key ingredient is at the minimum daily dose that will barely elevate the metabolic rate and is a whopping 87.5 % lower than the ideal fat burning dose.

With Thermonol XS you will never be subjected to this kind of highway robbery. You will always receive what is on the label. Every ingredient will be provided in the highest/safest dose that has been clinically shown to give you what you have been looking for …MAXIMUM and SAFE FAT LOSS.

Q. I noticed that your product contains an ingredient called forskolin. What is it and why is it in your product?

A. Forskolin is the preferred active ingredient of an herb called coleus forskohli, which is in the mint family of botanicals. Never heard of it? It’s not a surprise. Coleus has been hidden away in Ayurvedic (India) medicine cabinets for hundreds of years. Forskolin creates more energy expenditure then what the body for the autonomic and voluntary processes can use. The autonomic processes include things such as heartbeat and voluntary processes are things like walking. The excess energy expenditure is given off as heat. Thermonol? S complex consists of nutrients that are very effective in curbing appetite. Curbing the appetite is important because it prevents people from increasing their caloric intake. By not increasing calories, which are the building blocks of energy, you will be able to put the body in a marked caloric deficit. So since the caloric expenditure has increased but the caloric intake has not, your body has no choice but to focus on body fat stores for it source of energy.

Q. Is using a fat burner a good way to lose fat without having to exercise or pay attention to proper eating habits?

A. No fat burner on the market will yield a net fat loss greater than what can be achieved through a proper diet and exercise program. However no diet and exercise program alone can give you greater fat loss than what you will experience when you combine them with the most effective fat burner ever formulated, that formula is THERMONOL XS.

GEN recommends to first beginning a sensible yet aggressive workout program with particular focus on cardiovascular training and combine it with a sensible calorie/refined carbohydrate reduced diet. When you take THERMONOL XS in conjunction with a sensible fat-loss diet and exercise program, you can guarantee that you can increase the loss of body fat like you have never experience before!

Q. Why does your product label say, “THERMONOL XS is not intended for continuous usage. Do not exceed 5 weeks continuous usage without cycling off for a minimum of a week?”

A. Most compounds used in fat burning products can become less effective over time if used continuously. A classic example of this is coffee. If you don’t normally drink coffee at all and you start drinking 3 cups every morning, the stimulation that you feel the first few days is far greater than the stimulation that you will feel after 5 weeks of continually use.

With Thermonol XS, after 5 weeks of continuous use, the body will start to down regulate the number of receptor sites used to absorb the various compounds. This means that if you continue taking the product after 5 weeks; it would be significantly less effective at burning that unwanted body fat.

For best results, use as part of a calorie restricted diet and exercise program.

THERMONOL XS is not intended for continuous usage. Do not exceed 5 weeks continuous usage without cycling off for a minimum of a week.

Warnings:
Do not use if you are pregnant or nursing or if you are at risk of or are being treated for high blood pressure, liver, thyroid or psychiatric disease, diabetes, pernicious anemia, nervousness, anxiety, depression, seizure disorder, cardiac arrhythmia, stroke, pheochromacytoma, or difficulty in urination due to prostate enlargement. Consult your healthcare professional before use if your are taking an MAO inhibitor or any other prescription drug or dietary supplement containing ephedrine, pseudoephedrine, or phenylpropanolamine (ingredients found in certain allergy, cough, cold and weight control products). Exceeding recommended servings may cause serious adverse health effects including heart attack and stroke. Do not consume additional caffeine with this product as serious adverse health effects may occur. Discontinue use and consult your physician if dizziness, sleeplessness, tremors, nervousness, headache or heart palpitations occur. Always consult your physician before taking any dietary supplement. If you have trouble sleeping do not take 6 hours before bedtime.

The Maximum recommended usage of ephedrine for a healthy adult is no more than 100 mg in a 24-hour period for not more than 12 weeks. Improper use of ephedrine may be hazardous to a person’s health. KEEP OUT OF REACH OF CHILDREN. Not intended for persons under 18 years of age.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
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Effervescent Creatine by Gen

CREAVESCENTâ„¢ form of effervescent creatine was designed to be absorbed directly into the small intestine more quickly than any other form of creatine. It’s bioavailability is expected to be higher than traditional forms of creatine which means your body can access and utilize up to three times the amount of creatine that you consume! CREAVESCENTâ„¢ is prepackaged in convenient foil pouches, virtually eliminating all the fuss of measuring your dosage. CREAVESCENTâ„¢ delivers the exact 5-gram dosing you need to pack on mass. And no more of the stomach irritation you may have come to expect from regular creatine. PHEW! That’s a relief! New! Now contains 2 grams of L-Glutamine per serving! 2-Hydroxy-1, 2,3-Propanetricarboxylic Acid assists the breakdown of carbohydrates to the molecular level for immediate cellular absorption and also bonds with creatine allowing it to transport in liquid form. Sodium Hydrogen Carbonate is essential for maintaining osmotic equilibrium (cellular fluid levels).

Creatine monohydrate is universally recognized as the most effective performance-enhancing supplement available. Creatine has helped thousands experience increased strength, endurance, and energy giving them that extra competitive edge. But there’s one big problem with old-fashioned creatine powder: many athletes do not receive traditional creatine’s full benefits because of incomplete absorption. Creatine powder isn’t soluble in water and delivers less than half of the creatine ingested. Powdered creatine’s inferior solubility can even lead to stomach upset or cramping.

GEN proudly introduces Creavescent, a revolutionary, scientifically proven method of transporting creatine into muscle fibers with Total Creatine Transport (TCT). Creavescent solves the creatine absorption problem by bypassing the damaging effects of the digestive process. Creavescent is easily assimilated through the small intestine allowing the creatine to absorb three times more efficiently than traditional powder.

Creavescent also contains L-Glutamine, the most abundant amino acid found in muscle tissue cells. L-Glutamine influences muscle protein synthesis, growth hormone, glycogen storage, and enhances the immune system. Additionally, L- Glutamine decreases protein degradation (BCAA catabolism), resulting in bigger, stronger muscle cells.

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